DestroyTwitter is an Air-based Twitter app that I’ve quickly fallen in love with. Its tiny window* hides a slew of features. You can move between your live Twitter feed, replies, saved favorites and messages received and sent.
You can sort tweets by age, change your bio info, and even keep track of how many API calls you’ve made, which helps you avoid the time out issue. Finally, tweet away with the built-in URL shortener. I’m lovin’ it.
*My one wish is to be able to make the window taller. The devs note that re-tweeting is coming soon.

[...] of all Tweets sent are using an Adobe AIR application). DT consists of a series of canvases that constantly update and keep tweets [...]